lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence
نویسندگان
چکیده
منابع مشابه
Molecular Mechanisms of Cellular Senescence
Normal mammalian cells in culture have a limited life span and will eventually maintain a growth arrested state, referred to as replicative senescence. Usually induced by telomere shortening this form of arrest is irreversible in the sense that cells cannot be triggered to reenter proliferation by physiological mitotic stimuli like growth factors. Senescence may also occur prematurely in respon...
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The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling...
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In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin and other rapalogs suppress geroconversion, maintaining quiescence instead. Here we showed that ATP-competitive kinase inhibitors (Torin1 and PP242), which inhibit both mTORC1 and TORC2, also suppressed geroconversion. D...
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Senescence is an irreversible loss of cellular proliferative capacity and, together with apoptosis, is considered a major pathway to control cell proliferation. Senescent cells remain metabolically active but are permanently in growth arrest. Two types of senescence can be distinguished: replicative and stress-induced. Replicative senescence (RE) occurs by continuous telomere shortening after e...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2021
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2021.04.004